Fibroblast Growth Factor-23—A Potential Uremic Toxin
نویسندگان
چکیده
منابع مشابه
Fibroblast Growth Factor-23—A Potential Uremic Toxin
Fibroblast growth factor-23 (FGF23) is a circulating member of the FGF family produced mainly by the osteocytes and osteoblasts that can act as a hormone. The main action of FGF23 is to lower phosphatemia via the reduction of urinary phosphate reabsorption and the decrease of 1,25(OH)₂-D generation in the kidney. In the course of chronic kidney disease (CKD), plasma FGF23 concentration rises ea...
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The hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that occurs in about 15% of children infected with Escherichia coli O157:H7 and in an unknown fraction of cases after infection with other Shiga toxin (Stx)–producing Escherichia coli (STEC). HUS is characterized by nonimmune hemolytic anemia, thrombocytopenia, and renal insufficiency; its onset is approximately 1 wk after the ...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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In an effort to elucidate control mechanisms for developmentally programmed cell death, conditions were sought which rescue the cells destined to die. Three areas of mesodermal cell death in the chick wing were examined, the posterior necrotic zone (PNZ) , the opaque patch (OP) and apical mesoderm. The PNZ and OP are areas of normally programmed cell death whereas the apical mesoderm undergoes ...
متن کاملIntravenous Phosphate Loading Increases Fibroblast Growth Factor 23 in Uremic Rats
Oral phosphate loading and calcitriol stimulate Fibroblast growth factor 23 (FGF23) secretion, but the mechanisms underlying the stimulation of FGF23 remain to be studied. We compared the effect of intravenous phosphate loading with that of oral loading on FGF23 levels in normal and 5/6 nephrectomized uremic rats. Uremic rats (Nx) and sham-operated rats were fed a normal phosphate diet for 2 we...
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ژورنال
عنوان ژورنال: Toxins
سال: 2016
ISSN: 2072-6651
DOI: 10.3390/toxins8120369